Package: phase1PRMD 1.0.2

phase1PRMD: Personalized Repeated Measurement Design for Phase I Clinical Trials

Implements Bayesian phase I repeated measurement design that accounts for multidimensional toxicity endpoints and longitudinal efficacy measure from multiple treatment cycles. The package provides flags to fit a variety of model-based phase I design, including 1 stage models with or without individualized dose modification, 3-stage models with or without individualized dose modification, etc. Functions are provided to recommend dosage selection based on the data collected in the available patient cohorts and to simulate trial characteristics given design parameters. Yin, Jun, et al. (2017) <doi:10.1002/sim.7134>.

Authors:Lu Zhang, Jun Yin

phase1PRMD_1.0.2.tar.gz
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phase1PRMD.pdf |phase1PRMD.html✨
phase1PRMD/json (API)
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Bug tracker:https://github.com/luzhangstat/phase1prmd/issues

On CRAN:

7 exports 0.63 score 68 dependencies 11 scripts 210 downloads

Last updated 5 years agofrom:a7422ac922. Checks:OK: 1 NOTE: 6. Indexed: yes.

Exports:eff_suggesteff_summarynTTP_summarynTTP.arraypatlist.displayRunPRMDSimPRMD

Dependencies:arrayhelpersbase64encbslibcachemclicodacolorspacecpp11digestdplyrevaluatefansifarverfastmapfontawesomefsgenericsggplot2gluegridExtragtablehighrhtmltoolsisobandjquerylibjsonlitekableExtraknitrlabelinglatticelifecyclemagrittrMASSMatrixmemoisemgcvmimemunsellnlmepillarpkgconfigplyrR6rappdirsRColorBrewerRcppreshape2rjagsrlangrmarkdownrstudioapisassscalesstringistringrsvglitesvUnitsystemfontstibbletidyselecttinytexutf8vctrsviridisLitewithrxfunxml2yaml