Package: phase1PRMD
Type: Package
Date: 2020-03-08
Title: Personalized Repeated Measurement Design for Phase I Clinical
        Trials
Version: 1.0.2
Author: Lu Zhang, Jun Yin
Maintainer: Lu Zhang <luzhangstat@gmail.com>
Description: Implements Bayesian phase I repeated measurement design
        that accounts for multidimensional toxicity endpoints and
        longitudinal efficacy measure from multiple treatment cycles.
        The package provides flags to fit a variety of model-based
        phase I design, including 1 stage models with or without
        individualized dose modification, 3-stage models with or
        without individualized dose modification, etc. Functions are
        provided to recommend dosage selection based on the data
        collected in the available patient cohorts and to simulate
        trial characteristics given design parameters. Yin, Jun, et al.
        (2017) <doi:10.1002/sim.7134>.
SystemRequirements: JAGS (http://mcmc-jags.sourceforge.net)
Depends: R (>= 3.0.0), coda (>= 0.13), ggplot2, stats
Encoding: UTF-8
LazyData: true
Imports: rjags, arrayhelpers, MASS, reshape2, plyr, dplyr,
        RColorBrewer, gridExtra, kableExtra, knitr
RoxygenNote: 7.0.2
Suggests:
License: GPL (>= 2)
NeedsCompilation: no
Config/pak/sysreqs: cmake libfontconfig1-dev libfreetype6-dev
        libfribidi-dev make libharfbuzz-dev jags libicu-dev libpng-dev
        libuv1-dev libxml2-dev
Repository: https://luzhangstat.r-universe.dev
Date/Publication: 2020-03-09 05:54:18 UTC
RemoteUrl: https://github.com/luzhangstat/phase1prmd
RemoteRef: HEAD
RemoteSha: a7422ac9228cbf7ee72c5f259e502f57ec4f8f6c
Packaged: 2026-07-04 08:26:00 UTC; root